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KMID : 1123920040180020534
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 2 p.534 ~ p.537
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Inhibition of Platelet Aggregation by Anti-thyroglobulin Monoclonal Antibodies
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Shon Yun-Hee
Kim Cheorl-Ho
Jeon Byung-Hoon
Nam Kyung-Soo
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Abstract
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We produced twelve monoclonal antibodies(mAbs) against thyroglobulin and characterized the bindig profiles. Among them, three mAbs(TN-1, TN-2 and TN-3) were further characterized their binding specificities. TN-2 had a potent lupus anticoagulant activity and potentiated the anticoagulant effect of venom phospholipase A₂. he anticoagulant mechanism of TN-2 was elongation of the partial thromboplastin time and binding to phosphatidylserine which may have a pivot role in blood coagulation. And TN-2 was cross-reacted with ss-DNA and ds-DNA and had a characteristic of autoantibody. These results suggest that TN-2 may provide a useful tool for studying the correlation between autoimmune thyroiditis and its therapeutic effect.
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KEYWORD
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Platelet Aggregation, Anti-thyroglobulin Monoclonal Antibodies
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